Dexilend 60mg Capsule

Uses of Dexilend 60mg Capsule

• Gastro-oesophageal reflux disease
• Heartburn
• Erosive oesophagitis

How does Dexilend 60mg Capsule work?

Dexilend 60mg Capsule works by suppressing the secretion of acid production from the gastric parietal cells(cells that line the middle of the stomach and essentially secrete the gastric acid) by blocking the final step of acid production.

Side Effects of Dexilend 60mg Capsule

• Nausea
• Abdominal pain
• Flatulence
• Diarrhea
• Vomiting
• Bruising
• fatigue
• headache
• shortness of breath
• pale skin
• loss of appetite
• bleeding gums

Quick Suggestions:

• Dexilend 60 should be taken 1 hour before a meal, preferably in the morning.
• It is a well-tolerated medicine and provides relief for a long time.
• Avoid eating late at night or before bedtime.
• Inform your doctor if you get watery diarrhea, fever, or stomach pain that does not go away.
• Inform your doctor if you do not feel better after taking it for 14 days as you may be suffering from some other problem that needs attention.
• Long-term use of Dexilend 60 can cause weak bones and a deficiency of minerals such as magnesium. Take adequate dietary intake of calcium and magnesium or supplements as prescribed by your doctor.
• Consult your doctor right away if you develop decreased urination, edema (swelling due to fluid retention), lower back pain, nausea, fatigue, and rash or fever. These could be signs of a kidney problem.

Indication of Dexilend 60mg Capsule

Dexlansoprazole is used in the treatment of gastroesophageal reflux disease (acid reflux) and peptic ulcer disease.

Pharmacology

Indeed, Dexilend 60mg Capsule contains the R-enantiomer of lansoprazole, which is a proton pump inhibitor (PPI). PPIs like dexlansoprazole work by binding to the H+/K+-exchanging ATPase (proton pump) present in the gastric parietal cells. This action leads to the inhibition of acid secretion in the stomach, reducing the production of gastric acid. As a result, PPIs are commonly used to treat conditions associated with excessive acid production, such as gastroesophageal reflux disease (GERD) and peptic ulcers.

The dual-release formulation of dexlansoprazole in Dexilend 60mg Capsule ensures a prolonged effect, allowing for once-daily dosing, as opposed to older PPI formulations that may require multiple daily doses. This makes dexlansoprazole convenient and effective in managing acid-related disorders.

As with any medication, it is essential to take Dexilend 60mg Capsule as prescribed by a healthcare professional and to be aware of any potential side effects or drug interactions. If you have any concerns or questions about the medication, always consult with your doctor or pharmacist for personalized advice and guidance.

Dosage & Administration of Dexilend 60mg Capsule

The adult dose for Dexilend 60mg Capsule 10's for different conditions is as follows:

1. Erosive Esophagitis Healing (capsule): Take 60 mg orally once daily for up to 8 weeks.
2. Erosive Esophagitis Maintenance (capsule or DR): Take 30 mg orally once daily for up to 6 months to maintain healing of EE.
3. Gastroesophageal Reflux Disease (GERD): Take 30 mg orally once daily for 4 weeks to treat heartburn associated with symptomatic non-erosive GERD.

For hepatic impairment:

• Mild (Child-Pugh A): No dose adjustment necessary.
• Moderate (Child-Pugh B): Do not exceed 30 mg/day.
• Severe (Child-Pugh C): Not recommended.

For children aged 12 years and above, the same doses as adults apply for the treatment of erosive esophagitis and GERD.

Interaction

• Concomitant use of Anti-viral drugs like Rilpivirine Atazanavir or other anti-HIV medications along with dexlansoprazole should be avoided as dexlansoprazole may affect the antiviral drugs.
• Do not use Dexilend 60mg Capsule if you are on blood-thinning medication like warfarin or phenprocoumon as both the medicines together may lead to increased bleeding that might prove fatal.
• Dexilend 60mg Capsule when used along with methotrexate for the long term have shown to have a toxic effect.
• Dexlansoprazole reduces the absorption of medicines like iron salts, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, and ketoconazole/itraconazole which are dependent on gastric acidity for their mechanism.
• Inform your doctor if you are on St.John's Wort (a flowering plant used to treat mood and nervous system-related disorders) as it may decrease the efficiency of dexlansoprazole.
• Close monitoring is advised in patients who are on water pills (a class of drugs prescribed to remove excess salt and water from the body) like Bumetanide (Bumex), Furosemide (Lasix), along with Dexilend 60mg Capsule as diuretics tend to cause magnesium imbalance and dexlansoprazole worsens the condition.
• Discuss with your doctor any other medicine, herbal preparation, and supplements you are taking currently to avoid any possible drug interactions.

Contraindications

Patients with known hypersensitivity to any formulation component should not take dexlansoprazole.

Pregnancy & Lactation

there are no specific studies on the use of dexlansoprazole in pregnant women. However, there have been observational studies of lansoprazole (the R-enantiomer of dexlansoprazole) use during pregnancy that did not show any association with adverse pregnancy-related outcomes. Animal studies with lansoprazole, conducted on rats during organogenesis through lactation, showed potential effects on the offspring's femur weight, length, crown-rump length, and growth plate thickness (males only) on postnatal day 21, which were associated with reduced body weight gain. Therefore, pregnant women should be advised about the potential risk to the fetus when using dexlansoprazole.

Regarding lactation, there is no specific information about the presence of dexlansoprazole in human milk or its effects on breastfed infants. However, lansoprazole and its metabolites have been detected in rat milk. Considering the developmental and health benefits of breastfeeding, the decision to use dexlansoprazole in lactating women should be made while considering the mother's clinical need for therapy and the potential adverse effects on the breastfed child from the treatment or the underlying maternal condition.

As always, pregnant and breastfeeding women should consult their healthcare provider before using any medication to assess potential risks and benefits. The information provided here is based on available data up to the time of the knowledge cutoff (September 2021), and new information may have emerged since then.

Precautions & Warnings

Regarding Dexilend 60mg Capsule, it is essential to follow the precautions and consult a doctor, especially if you have any pre-existing medical conditions or allergies. Here are the key points to consider:

• Consult with a doctor if you have any type of disease, especially severe liver disease, osteoporosis, low bone mineral density (osteopenia), or low levels of magnesium in your blood before taking Dexilend 60mg Capsule 10's.
• Inform your doctor about any known allergies to any of the components present in Dexilend 60mg Capsule 10's to avoid potential unwanted side effects.
• Long-term treatment with Dexilend 60mg Capsule 10's may cause low magnesium levels and vitamin B12 levels. The doctor may advise regular tests to monitor your condition.
• Pregnant and breastfeeding women should avoid taking Dexilend 60mg Capsule unless prescribed by a healthcare professional.
• Dexilend 60mg Capsule may cause dizziness and sleepiness, so avoid activities that require alertness, such as driving, until you know how the medication affects you.
• The safety of the Dexilend 60mg Capsule has not been established for use in children, so it should not be given to children without appropriate medical supervision.
• Avoid consuming alcohol while taking Dexilend 60mg Capsule, as it may increase drowsiness and elevate stomach acid production.
• Prolonged intake of Dexilend 60mg Capsules may be associated with a greater risk of Clostridium difficile-associated diarrhea. If you develop persistent diarrhea, seek immediate medical attention.

Keep your doctor informed about your health condition and all the medicines you are taking to avoid any potential drug interactions or side effects.

Storage Conditions

• Store this drug at room temperature. Keep it between 68°F and 77°F (20°C and 25°C).
• Don’t store this medication in moist or damp areas, such as bathrooms.